β-肾上腺素能受体阻滞剂的药代动力学与口服避孕药
Beta-adrenoceptor blocker pharmacokinetics and the oral contraceptive pill.
作者信息
Kendall M J, Jack D B, Quarterman C P, Smith S R, Zaman R
出版信息
Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):87S-89S. doi: 10.1111/j.1365-2125.1984.tb02435.x.
Abstract
Higher AUC and Cmax values were obtained for metoprolol, oxprenolol and propranolol in groups receiving the low-dose oestrogen-ethinyl oestradiol oral contraceptive, but statistical significance was reached only with metoprolol AUC. The oral contraceptive had the opposite effect on acebutolol AUC and Cmax but this was not significant. The oral contraceptive had no detectable effects on the tmax and t 1/2 values of any of the beta-adrenoceptor blockers.
摘要
在接受低剂量雌激素 - 炔雌醇口服避孕药的组中，美托洛尔、氧烯洛尔和普萘洛尔获得了更高的AUC和Cmax值，但仅美托洛尔的AUC达到了统计学显著性。口服避孕药对醋丁洛尔的AUC和Cmax有相反的作用，但不显著。口服避孕药对任何一种β - 肾上腺素能阻滞剂的tmax和t 1/2值均无明显影响。
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