Karpinski E, Barton S, Longridge D, Schachter M
Can J Physiol Pharmacol. 1984 Jun;62(6):650-3. doi: 10.1139/y84-106.
Vasoactive intestinal polypeptide (VIP) is a powerful vasodilator agent in the submandibular gland of the cat, and its effect can be reduced by avian pancreatic polypeptide (APP), or by desensitization of the gland's blood vessels to VIP. However, the vasodilatation caused by parasympathetic nerve stimulation is not reduced by either of these means. We conclude, therefore, that VIP is unlikely to be a major mediator of this atropine-resistant vasodilatation. Experiments with a potentiator of acetylcholine, eserine, and with a depleter, suggest that acetylcholine plays some role in this vasodilatation, but it too does not appear to be the major physiological mechanism. Substance P and ATP were neither potent nor consistent vasodilators and are unlikely mediators.
血管活性肠肽（VIP）是猫下颌下腺中一种强大的血管舒张剂，其作用可被禽胰多肽（APP）或通过使腺体血管对VIP脱敏而减弱。然而，副交感神经刺激引起的血管舒张不会因上述任何一种方式而减弱。因此，我们得出结论，VIP不太可能是这种对阿托品耐药的血管舒张的主要介质。用乙酰胆碱增强剂毒扁豆碱和排空剂进行的实验表明，乙酰胆碱在这种血管舒张中起一定作用，但它似乎也不是主要的生理机制。P物质和三磷酸腺苷既不是强效的也不是持续的血管舒张剂，不太可能是介质。
