5-羟色胺脱敏不能改变豚鼠结肠中γ-氨基丁酸诱导的抑制反应。

5-hydroxytryptamine desensitization fails to modify GABA-induced inhibitory responses in the guinea-pig colon.

作者信息

Onori L, Saltarelli P, Marcoli M, Lecchini S, Frigo G M, Tonini M

出版信息

J Pharm Pharmacol. 1984 Jun;36(6):406-8. doi: 10.1111/j.2042-7158.1984.tb04410.x.

DOI:10.1111/j.2042-7158.1984.tb04410.x

Abstract

In segments of guinea-pig colon, treated with 1 microM hyoscine, a 5-HT desensitization procedure that decreased the potency of 5-HT 41-fold in relaxing the longitudinal musculature, failed to modify the non-adrenergic GABA-induced inhibitory responses, suggesting that the action of GABA in this preparation is not 5-HT-mediated. These results are at variance with those obtained in the guinea-pig ileum where 5-HT seems to play a role in GABA-induced cholinergic contractions.

摘要

在豚鼠结肠段用1微摩尔东莨菪碱处理后，一种5-羟色胺脱敏程序使5-羟色胺在舒张纵行肌方面的效力降低了41倍，但未能改变非肾上腺素能GABA诱导的抑制反应，这表明在该制剂中GABA的作用不是由5-羟色胺介导的。这些结果与在豚鼠回肠中获得的结果不同，在豚鼠回肠中5-羟色胺似乎在GABA诱导的胆碱能收缩中起作用。