Shephard R A, Estall L B
Neuropharmacology. 1984 Jun;23(6):677-81. doi: 10.1016/0028-3908(84)90150-3.
The effects of chlordiazepoxide (0,2.5 and 7.5 mg/kg), of valproate (0,100 and 300 mg/kg), and of combinations of these drugs, on hyponeophagia in rats, were studied using a food preference test. Chlordiazepoxide alone reduced the latency for eating, and also enhanced the time of eating and the amount of familiar food eaten at the smaller dose, and of novel food eaten at the larger dose. Valproate alone reduced the latency of eating and enhanced time of eating and the amount of novel food eaten, especially at 300 mg/kg. However, valproate antagonised the effects of chlordiazepoxide on all behavioural measures. These findings are discussed in the context of the GABA hypothesis of the actions of benzodiazepines, with the conclusion that valproate has an atypical pharmacological profile amongst putative GABA agonists, and may have partial agonist activity at the proposed benzodiazepine/GABA receptor complex.
采用食物偏好试验，研究了氯氮卓（0、2.5和7.5毫克/千克）、丙戊酸盐（0、100和300毫克/千克）以及这些药物组合对大鼠食欲减退的影响。单独使用氯氮卓可缩短进食潜伏期，小剂量时还可延长进食时间并增加熟悉食物的摄入量，大剂量时则增加新奇食物的摄入量。单独使用丙戊酸盐可缩短进食潜伏期，延长进食时间并增加新奇食物的摄入量，尤其是在300毫克/千克时。然而，丙戊酸盐拮抗了氯氮卓对所有行为指标的影响。这些发现结合苯二氮卓类药物作用的GABA假说进行了讨论，得出的结论是，丙戊酸盐在假定的GABA激动剂中具有非典型的药理学特征，并且可能在拟议的苯二氮卓/GABA受体复合物处具有部分激动剂活性。
