胆总管切开术后胆汁酶活性及类固醇治疗的效果。
Bile enzyme activities following choledochotomy and the effect of steroid treatment.
作者信息
Edes I, Edes I
出版信息
Acta Med Hung. 1984;41(2-3):143-7.
The alkaline phosphatase (AP) and gamma-glutamyl-transpeptidase (GGT) activities and the effect of steroid treatment were studied in human bile and serum following choledochotomy. Activity of the two enzymes in the bile changed in parallel. Following the operation the enzyme activities initially decreased, but after 3 days they showed a progressive increase and reached their maximum on day 6. It appears that the bile is a major route for the elimination of both enzymes from the damaged liver. 60 mg Prednisolone on the day of operation and 2 days after surgical intervention prevented the initial decline in enzyme activity and significantly increased the excretion of enzymes. The possible pathogenesis of enzymatic changes after choledochotomy is discussed.
在胆总管切开术后，对人胆汁和血清中的碱性磷酸酶（AP）和γ-谷氨酰转肽酶（GGT）活性以及类固醇治疗的效果进行了研究。胆汁中这两种酶的活性呈平行变化。术后酶活性最初下降，但3天后逐渐升高，并在第6天达到最高值。看来胆汁是受损肝脏清除这两种酶的主要途径。手术当天及手术干预后2天给予60mg泼尼松龙可防止酶活性的初始下降，并显著增加酶的排泄。本文讨论了胆总管切开术后酶变化的可能发病机制。
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