Warren D, Cornelius C, Ford B
Vet Hum Toxicol. 1984 Aug;26(4):295-9.
Hydrazine sulfate (Hs), a known occupational toxin and putative cancer therapeutic agent, was administered iv at various doses to rhesus monkeys in an effort to measure its effects upon the liver. Function tests included indocyanine clearance (ICG Vmax and Km), serum bile acid levels and serum enzyme activities, including alanine aminotransferase, gamma glutamyl transferase, and a panel of 19 other blood chemical constituents. Hepatic function and other biochemical tests were generally within the normal range following single-dose Hs administration (10-40 mg/kg) and did not suggest the presence of significant liver injury. Two monkeys receiving 80 mg/kg Hs exhibited extensive hepatic lipidosis without biochemical or histologic signs of necrosis. Hs, administered iv, appears to produce little or no hepatic toxicity.
硫酸肼（Hs）是一种已知的职业毒素和假定的癌症治疗剂，以不同剂量静脉注射给恒河猴，以测定其对肝脏的影响。功能测试包括吲哚菁清除率（ICG Vmax和Km）、血清胆汁酸水平以及血清酶活性，包括丙氨酸转氨酶、γ-谷氨酰转移酶以及其他19种血液化学成分。单剂量给予硫酸肼（10 - 40mg/kg）后，肝功能和其他生化测试一般在正常范围内，未提示存在明显肝损伤。两只接受80mg/kg硫酸肼的猴子出现广泛的肝脏脂肪变性，但无坏死的生化或组织学迹象。静脉注射硫酸肼似乎几乎不产生或不产生肝毒性。
