尼古丁诱导猫流涎：多种药物的作用

Nicotine-induced salivation in cats: effects of various drugs.

作者信息

Beleslin D B, Krstić S K, Tomić-Beleslin N

出版信息

Brain Res Bull. 1984 May;12(5):585-7. doi: 10.1016/0361-9230(84)90177-1.

Abstract

The effect of an intracerebroventricular injection of an antimuscarinic drug, ganglionic blocking agent, alpha and beta adrenergic blocking drug, antiserotonin agent or antihistamine upon salivation produced by nicotine similarly injected in the cat was investigated. Atropine and hexamethonium abolished the salivation evoked by nicotine. On the other hand, salivation induced by nicotine was not significantly altered by yohimbine, practolol, methysergide and antazoline. It is concluded that the salivation produced by nicotine is mediated via central receptors which have mixed nicotinic and muscarinic properties.

摘要

研究了向猫脑室内注射抗毒蕈碱药物、神经节阻断剂、α和β肾上腺素能阻断药物、抗血清素剂或抗组胺药对同样注射尼古丁后引起的唾液分泌的影响。阿托品和六甲铵消除了尼古丁引起的唾液分泌。另一方面，育亨宾、心得宁、麦角新碱和安他唑啉对尼古丁诱导的唾液分泌没有显著影响。得出的结论是，尼古丁引起的唾液分泌是通过具有烟碱和毒蕈碱混合特性的中枢受体介导的。