Beleslin D B, Krstić S K
Pharmacol Biochem Behav. 1986 Jun;24(6):1509-11. doi: 10.1016/0091-3057(86)90476-4.
The effects were investigated of intracerebroventricular (ICV) injections in the cat of ganglionic blocking agents, antimuscarinic drugs, alpha and beta adrenergic blocking substances, dopamine antagonists, an antihistamine, reserpine and a 5-hydroxytryptamine antagonist as well as the inhibitors of catecholamines, 5-hydroxytryptamine and acetylcholine synthesis upon convulsions produced by nicotine, which was similarly injected. Mecamylamine and hexamethonium but not atropine, scopolamine, yohimbine, phenoxybenzamine, tolazoline, propranolol, practolol, chlorpromazine, haloperidol, antazoline and methysergide abolished the convulsions evoked by nicotine. Furthermore, reserpine, but not 6-hydroxydopamine, as well as 5,6-dihydroxytryptamine and hemicholinium blocked the convulsions caused by nicotine. It appears, therefore, that the convulsions produced by nicotine are mediated through central nicotinic receptors. However, the depressed catecholaminergic, 5-hydroxytryptaminergic and histaminergic mechanisms induced by reserpine can also suppress the convulsions evoked by nicotine.
研究了向猫脑室内注射神经节阻断剂、抗毒蕈碱药物、α和β肾上腺素能阻断物质、多巴胺拮抗剂、抗组胺药、利血平、5-羟色胺拮抗剂以及儿茶酚胺、5-羟色胺和乙酰胆碱合成抑制剂后，对由同样注射的尼古丁所引发惊厥的影响。美加明和六甲双铵可消除尼古丁诱发的惊厥，而阿托品、东莨菪碱、育亨宾、酚苄明、妥拉唑啉、普萘洛尔、普拉洛尔、氯丙嗪、氟哌啶醇、安他唑啉和麦角新碱则不能。此外，利血平可阻断尼古丁引起的惊厥，而6-羟基多巴胺、5,6-二羟基色胺和半胱胺则不能。因此，尼古丁引发的惊厥似乎是通过中枢烟碱受体介导的。然而，利血平所诱导的儿茶酚胺能、5-羟色胺能和组胺能机制的抑制也可抑制尼古丁诱发的惊厥。
