Holmes R, Mooney V, Bucholz R, Tencer A
Clin Orthop Relat Res. 1984 Sep(188):252-62.
Experimental histologic and biomechanical studies were performed in 52 dogs by use of a bone substitute composed of hydroxyapatite converted from sea coral calcite. The results demonstrate some potentially useful practical applications. The material was totally incorporated in bone. Although initially too weak to tolerate physiologic stresses, once incorporated it becomes almost as strong as the native bone. Clinical experience with internal fixation of fractures with hydroxyapatite in 18 patients is encouraging.
利用由海珊瑚方解石转化而来的羟基磷灰石组成的骨替代物，对52只狗进行了实验性组织学和生物力学研究。结果证明了一些潜在有用的实际应用。该材料完全融入了骨组织。尽管最初它太脆弱，无法承受生理应力，但一旦融入，它就变得几乎与天然骨一样坚固。18例患者使用羟基磷灰石进行骨折内固定的临床经验令人鼓舞。
