三唑仑的蛋白结合及其与α1酸性糖蛋白浓度的相关性。
Triazolam protein binding and correlation with alpha-1 acid glycoprotein concentration.
作者信息
Kroboth P D, Smith R B, Sorkin M I, Silver M R, Rault R, Garry M, Juhl R P
出版信息
Clin Pharmacol Ther. 1984 Sep;36(3):379-83. doi: 10.1038/clpt.1984.191.
On two occasions separated by a minimum of 1 wk, plasma was obtained from 12 patients (aged 18 to 73 yr) on dialysis after an overnight fast. Samples were assayed for albumin and alpha 1-acid glycoprotein (AGP) concentrations. 14C-Triazolam was added to each sample to a final concentration of 5 ng/ml. Protein binding was determined by equilibrium dialysis. Unbound triazolam ranged from 6.4% to 15.4% (mean = 10.0%). AGP concentrations ranged from 71.8 to 205.1 mg% (mean = 123.4 mg%). Triazolam binding ratio (bound/unbound concentration) correlated with AGP concentration (r2 = 0.69) but not with albumin concentration, age, or sex. This correlation was verified by adding AGP in varying amounts to control plasma.
在间隔至少1周的两个时间点，对12名接受透析的患者（年龄在18至73岁之间）进行过夜禁食后采集血浆。对样本检测白蛋白和α1-酸性糖蛋白（AGP）浓度。向每个样本中加入14C-三唑仑，使其终浓度达到5 ng/ml。通过平衡透析法测定蛋白结合率。未结合的三唑仑范围为6.4%至15.4%（平均值 = 10.0%）。AGP浓度范围为71.8至205.1 mg%（平均值 = 123.4 mg%）。三唑仑结合率（结合/未结合浓度）与AGP浓度相关（r2 = 0.69），但与白蛋白浓度、年龄或性别无关。通过向对照血浆中加入不同量的AGP验证了这种相关性。
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