Büsing C M, Steinleitner W
Exp Pathol. 1984;25(4):199-204. doi: 10.1016/s0232-1513(84)80021-3.
Heart muscle necroses can be produced in rabbits by normobaric hyperoxia. The pathogenesis of these lesions is controversial. In our investigations we found that such necroses can be prevented by beta blockers, but not by a calcium antagonist. This can be explained by the different action of the two drugs on the coronary arteries. The result supports the view that heart muscle necroses after normobaric hyperoxia are a direct toxic effect of oxygen on the heart muscle fibers.
常压高氧可使兔产生心肌坏死。这些病变的发病机制存在争议。在我们的研究中，我们发现此类坏死可被β受体阻滞剂预防，但不能被钙拮抗剂预防。这可以通过两种药物对冠状动脉的不同作用来解释。该结果支持以下观点：常压高氧后的心肌坏死是氧气对心肌纤维的直接毒性作用。
