Shann F, Gratten M, Germer S, Linnemann V, Hazlett D, Payne R
Lancet. 1984 Sep 8;2(8402):537-41. doi: 10.1016/s0140-6736(84)90764-5.
To determine the aetiology of pneumonia in 83 children admitted to Goroka Hospital, Papua New Guinea, lung aspirates and blood were cultured for bacteria. Haemophilus infuenzae, Streptococcus pneumoniae, or both, were isolated from 43 (52%) of the children, other bacteria from 8 (10%), and no bacteria from 32 (39%). Of the 32 strains of H influenzae tested, 18 (56%) were non-serotypable, 8 (25%) were serotypes other than type b, and only 6 (19%) were type b. Viruses were isolated from lung or nasopharyngeal aspirates from 18 (29%) of the 62 children for whom viral cultures were done. It seems that, although viruses may initiate infection, death from pneumonia in children in developing countries is often due to H influenzae, S pneumoniae, or both. Antibiotic therapy would prevent many of these deaths. There is an urgent need for vaccines, effective in children less than 6 months old, that protect against all strains of H influenzae, and S pneumoniae.
为确定巴布亚新几内亚戈罗卡医院收治的83名儿童肺炎的病因,对其肺穿刺液和血液进行了细菌培养。从43名(52%)儿童中分离出流感嗜血杆菌、肺炎链球菌或二者皆有,8名(10%)儿童分离出其他细菌,32名(39%)儿童未分离出细菌。在检测的32株流感嗜血杆菌中,18株(56%)不可分型,8株(25%)为b型以外的血清型,仅6株(19%)为b型。在进行病毒培养的62名儿童中,18名(29%)从肺或鼻咽抽吸物中分离出病毒。看起来,尽管病毒可能引发感染,但发展中国家儿童肺炎死亡往往是由流感嗜血杆菌、肺炎链球菌或二者共同所致。抗生素治疗可预防许多此类死亡。迫切需要能有效保护6个月以下儿童抵御所有流感嗜血杆菌菌株和肺炎链球菌的疫苗。