Akasu T, Shinnick-Gallagher P, Gallagher J P
Nature. 1984;311(5981):62-5. doi: 10.1038/311062a0.
Considerable evidence has accumulated suggesting that purines, adenosine and ATP function as neurotransmitters in the central and peripheral nervous systems. Burnstock has proposed that purinergic receptors be classified into two types, P1 and P2, having adenosine and ATP, respectively, as agonist prototypes. Recent data suggest that ATP may mediate a synaptic potential in guinea pig vas deferens, but no such evidence exists for adenosine. The presence of a non-cholinergic, non-adrenergic nerve supply to the urinary bladder has been postulated and termed purinergic, as these nerves have been shown to release ATP. Furthermore, atropine-resistant contractions of bladder smooth muscle are thought to be mediated by ATP, while in situ experiments in vesical parasympathetic ganglia have suggested that a purinergic modulatory mechanism may control urinary bladder function. We now report the presence of a slow hyperpolarizing synaptic potential (slow-h.s.p.) in neurones of cat vesical parasympathetic ganglia, produced by stimulating the preganglionic nerves, and provide evidence that the slow-h.s.p. is mediated by adenosine.
大量证据表明，嘌呤、腺苷和三磷酸腺苷（ATP）在中枢和外周神经系统中作为神经递质发挥作用。伯恩斯托克提出，嘌呤能受体可分为两种类型，P1和P2，分别以腺苷和ATP作为激动剂原型。最近的数据表明，ATP可能介导豚鼠输精管的突触电位，但腺苷尚无此类证据。据推测，膀胱存在非胆碱能、非肾上腺素能神经供应，称为嘌呤能神经，因为这些神经已被证明可释放ATP。此外，膀胱平滑肌对阿托品抵抗的收缩被认为是由ATP介导的，而膀胱副交感神经节的原位实验表明，嘌呤能调节机制可能控制膀胱功能。我们现在报告，刺激猫膀胱副交感神经节的节前神经可在其中枢神经元中产生缓慢超极化突触电位（slow-h.s.p.），并提供证据表明slow-h.s.p.由腺苷介导。
