Athanassious R, Klyne M A, Ali M A
Cell Tissue Res. 1984;237(1):95-101. doi: 10.1007/BF00229203.
The distribution of cyclases in retinal photoreceptors of dark- and light-adapted brook trout was studied by means of a cytochemical method (lead precipitation). It confirms earlier reports that retinal photoreceptors contain high levels of cyclic nucleotides, and that cAMP predominates in cones and cGMP in rods. There is an apparent difference in the level of the cyclases with the adaptive states. In addition, the catalytic unit of cyclase is interlamellar in cones. In rods, adenylate cyclase is intradiscal, while the location of guanylate cyclase varies with the adaptive state. The variation of cyclase with adaptation indicates that this enzyme has a role in the process of visual transduction.
采用细胞化学方法（铅沉淀法）研究了暗适应和光适应溪鳟视网膜光感受器中环化酶的分布。该研究证实了早期的报道，即视网膜光感受器含有高水平的环核苷酸，视锥细胞中以环磷酸腺苷（cAMP）为主，视杆细胞中以环磷酸鸟苷（cGMP）为主。环化酶的水平在不同适应状态下存在明显差异。此外，视锥细胞中环化酶的催化单位位于片层间。在视杆细胞中，腺苷酸环化酶位于盘内，而鸟苷酸环化酶的位置随适应状态而变化。环化酶随适应状态的变化表明该酶在视觉转导过程中起作用。
