Palatini P, Pessina A C, Sperti G, Fortunato V, Gava R, Dal Palù C
G Ital Cardiol. 1984 Jun;14(6):401-6.
Twelve patients with severe hypertension of different causes, resistant to conventional antihypertensive agents and also to maximum doses of either minoxidil or captopril added to other combinations, were effectively controlled with the association of small doses of minoxidil and captopril plus a diuretic and a beta-blocker. The untoward effects which were previously present in all the patients with maximum doses of minoxidil and in one of the patients treated with captopril disappeared or greatly diminished shortly after this association was started. The different mechanisms of action and opposite side effects of minoxidil and captopril provide the rationale for a combined treatment with the two drugs.
12例病因各异的重度高血压患者，对传统抗高血压药物耐药，即便在其他联合用药基础上加用最大剂量的米诺地尔或卡托普利也无法控制病情，但采用小剂量米诺地尔、卡托普利联合利尿剂和β受体阻滞剂治疗后，血压得到有效控制。此前使用最大剂量米诺地尔治疗的所有患者以及使用卡托普利治疗的1例患者出现的不良反应，在开始联合用药后不久即消失或显著减轻。米诺地尔和卡托普利不同的作用机制及相反的副作用，为两药联合治疗提供了理论依据。
