Jones R C
Int J Fertil. 1984;29(2):122-8.
A single injection of the LRH agonist, Wy-40,972, under the right ovarian bursa (IB) on any individual day (D) 1-7 in the pregnant rat increased still further the compensatory ovarian weight gain produced by hemicastration (HC) alone. Conversely, a single subcutaneous (sc) injection during the same period abolished the compensatory hypertrophy and reduced the weight of the remaining ovary to that of the ovary of the intact rat and below. The single sc or IB injections of Wy-40,972 were most effective in delaying implantation when administered on D3-4 or 4, respectively. Subcutaneous administration on D5, 6, or 7 produced an antifertility effect, whereas IB administration on any of these 3 days failed to modify the pregnancy. These data demonstrate that the LRH agonist, Wy-40,972, acts directly on the ovary with regard to both weight increase and delay of blastocyst implantation. The results are discussed in relation to hormonal requirements for implantation and desensitization of the ovary.
在怀孕大鼠的任何第1 - 7天，于右侧卵巢囊（IB）单次注射促黄体生成素释放激素（LRH）激动剂Wy - 40,972，会进一步增加仅由半侧卵巢切除（HC）所产生的代偿性卵巢重量增加。相反，在同一时期进行单次皮下（sc）注射则会消除代偿性肥大，并使剩余卵巢的重量降至完整大鼠卵巢的重量及以下。当分别在第3 - 4天或第4天进行单次sc或IB注射Wy - 40,972时，对延迟着床最为有效。在第5、6或7天进行皮下给药会产生抗生育作用，而在这3天中的任何一天进行IB给药均未能改变妊娠情况。这些数据表明，LRH激动剂Wy - 40,972在卵巢重量增加和胚泡着床延迟方面均直接作用于卵巢。结合着床的激素需求和卵巢脱敏对结果进行了讨论。
