阿地唑仑及其代谢物的生物活性测定。
Determination of biological activity of adinazolam and its metabolites.
作者信息
Sethy V H, Collins R J, Daniels E G
出版信息
J Pharm Pharmacol. 1984 Aug;36(8):546-8. doi: 10.1111/j.2042-7158.1984.tb04449.x.
Abstract
Adinazolam and its metabolites inhibit [3H]flunitrazepam binding in-vitro. The binding affinities of these compounds is significantly enhanced in the presence of 10-5 M muscimol, indicating that both adinazolam and its metabolites are benzodiazepine agonists. In-vivo metabolism of adinazolam results in the formation of active metabolites.
摘要
阿地唑仑及其代谢产物在体外可抑制[3H]氟硝西泮结合。在10-5 M蝇蕈醇存在的情况下，这些化合物的结合亲和力显著增强，这表明阿地唑仑及其代谢产物均为苯二氮䓬类激动剂。阿地唑仑的体内代谢会导致活性代谢产物的形成。
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