Cassidy M K, Houston J B
J Pharm Pharmacol. 1984 Aug;36(8):550-2. doi: 10.1111/j.2042-7158.1984.tb04451.x.
The systemic availability of phenol following rectal administration to rats has been compared to intraduodenal and intravenous administration via the hepatic portal and jugular veins. Phenol blood concentration-time curves after the rectal route of dosing indicate that first pass conjugation by the intestinal mucosa and liver is drastically reduced when compared to the other routes of administration.
已将大鼠直肠给药后苯酚的全身可用性与通过肝门静脉和颈静脉进行的十二指肠内给药及静脉内给药进行了比较。直肠给药途径后的苯酚血药浓度-时间曲线表明，与其他给药途径相比，肠黏膜和肝脏的首过结合作用大幅降低。
