Kappa-opioid diuretic effects of tifluadom, a benzodiazepine opioid agonist.

Tifluadom produced a dose-related (0.08-5 mg kg-1) diuresis in normally hydrated rats. This diuretic effect was antagonized by kappa-antagonist doses of naloxone and blocked by morphine administration. This is further in-vivo evidence that tifluadom is a fairly specific kappa-opioid agonist.