Van Sweden B
Acta Psychiatr Belg. 1984 May-Jun;84(3):235-9.
This case report is one of the few observations in man showing REM-latency reduction as one of the neurophysiological consequences of abrupt neuroleptic suspension. One should take care not to attribute diagnostic significance to EEG or sleep-features which may be drug-dependent. The underlying neurochemical mechanisms are discussed, transient cholinergic overactivity is emphasized in neuroleptic withdrawal.
本病例报告是少数关于人类的观察报告之一，显示快速眼动睡眠潜伏期缩短是突然停用抗精神病药物的神经生理学后果之一。应注意不要将可能依赖药物的脑电图或睡眠特征赋予诊断意义。文中讨论了潜在的神经化学机制，强调了抗精神病药物撤药时短暂的胆碱能活性过强。
