纳多洛尔对原发性高血压患者的长期肾脏血流动力学影响。

Long-term renal hemodynamic effects of nadolol in patients with essential hypertension.

作者信息

Frohlich E D, Messerli F H, Deslinski G R, Kobrin I

出版信息

Am Heart J. 1984 Oct;108(4 Pt 2):1141-3. doi: 10.1016/0002-8703(84)90596-9.

Abstract

Renal and systemic hemodynamic effects of nadolol, a nonselective beta-adrenergic-blocking agent, were determined over a 2-year period in eight patients with essential hypertension. Arterial pressure and heart rate remained significantly reduced for the full 2 years in all eight patients. Renal blood flow and plasma volume remained unchanged, and renal vascular resistance significantly decreased. Serum creatinine levels decreased from pretreatment values, suggesting improved glomerular filtration rates. These data demonstrate the favorable renal hemodynamic effects of nadolol monotherapy in patients with uncomplicated essential hypertension during a prolonged treatment program.

摘要

在两年时间里，对8例原发性高血压患者测定了非选择性β肾上腺素能阻滞剂纳多洛尔对肾脏和全身血流动力学的影响。在所有8例患者中，动脉压和心率在整整两年中均显著降低。肾血流量和血浆容量保持不变，肾血管阻力显著下降。血清肌酐水平较治疗前值降低，提示肾小球滤过率有所改善。这些数据表明，在长期治疗方案中，纳多洛尔单药治疗对无并发症的原发性高血压患者具有良好的肾脏血流动力学效应。