Nelkin B D, Rosenfeld K I, de Bustros A, Leong S S, Roos B A, Baylin S B
Biochem Biophys Res Commun. 1984 Sep 17;123(2):648-55. doi: 10.1016/0006-291x(84)90278-x.
Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.
在一种人甲状腺髓样癌细胞系中已检测到降钙素（CT）和降钙素基因相关肽（CGRP）的信使核糖核酸。它们克隆的互补脱氧核糖核酸的DNA序列以及基因组限制性图谱表明，这两种信使核糖核酸可能都源自单个基因；不同的信使核糖核酸是通过可变加工产生的。降钙素基因在10个检测的人肺癌培养细胞系中均有表达；其中大多数细胞系表达的CGRP与CT特异性信使核糖核酸的比例高于甲状腺髓样癌细胞系。
