α-甲基去甲肾上腺素对大鼠颌下腺和腮腺蛋白质及电解质分泌的影响。

The effects of alpha-methylnoradrenaline on protein and electrolyte secretion by rat submandibular and parotid glands.

作者信息

Abe K, Dawes C

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;78(2):383-9. doi: 10.1016/0742-8413(84)90103-8.

Abstract

alpha-Methylnoradrenaline (alpha-mNA) is a potent secretagogue for the parotid and submandibular glands of rats. With regard to the parotid glands, alpha-mNA activates mainly beta-adrenoceptors. In the submandibular glands, alpha-mNA activates alpha-adrenoceptors at higher doses whereas at relatively lower doses it activates beta-adrenoceptors. alpha-mNA may not stimulate the specific alpha 2-adrenoceptors of the salivary glands of rats.

摘要

α-甲基去甲肾上腺素（α-mNA）是大鼠腮腺和颌下腺的一种强效促分泌素。对于腮腺，α-mNA主要激活β-肾上腺素能受体。在颌下腺中，高剂量时α-mNA激活α-肾上腺素能受体，而在相对较低剂量时它激活β-肾上腺素能受体。α-mNA可能不会刺激大鼠唾液腺的特异性α2-肾上腺素能受体。