Majumdar S K, Shaw G K, Bridges P K
Drug Alcohol Depend. 1984 Sep;14(1):45-9. doi: 10.1016/0376-8716(84)90018-8.
Plasma cortisol levels were estimated by the competitive protein binding (CPB) method with radioactive selenium-75 in 32 male chronic alcoholics with depression. The degree of depression was rated by the Hamilton Depression Rating Scale (HDRS). Duration of drinking ranged from 5-25 years with an average daily amount of ethanol intake of 100-150 g (equivalent to half a bottle of spirits). Plasma cortisol levels were often raised in drinking chronic alcoholics and there was a strongly positive and statistically highly significant correlation between them and depression ratings (r = +0.56; P = 0.001). It is possible that the diurnal rhythm of cortisol secretion is disturbed or adreno-cortical activity is stimulated in these patients due to chronic ethanol ingestion. It is further suggested that brain serotonin deficiency known to occur in chronic alcoholics might lead to raised plasma cortisol levels in ethanol-induced depression.
采用放射性硒 - 75的竞争性蛋白结合（CPB）法对32名伴有抑郁症的男性慢性酒精中毒者的血浆皮质醇水平进行了评估。抑郁症的严重程度通过汉密尔顿抑郁量表（HDRS）进行评定。饮酒时间为5至25年，每日乙醇摄入量平均为100至150克（相当于半瓶烈酒）。慢性酒精中毒饮酒者的血浆皮质醇水平常常升高，且它们与抑郁评分之间存在强正相关且在统计学上具有高度显著性（r = +0.56；P = 0.001）。由于长期摄入乙醇，这些患者的皮质醇分泌昼夜节律可能受到干扰，或者肾上腺皮质活动受到刺激。进一步表明，已知慢性酒精中毒者会出现的脑血清素缺乏可能导致乙醇诱导的抑郁症患者血浆皮质醇水平升高。
