Tullus K, Hörlin K, Svenson S B, Källenius G
J Infect Dis. 1984 Nov;150(5):728-36. doi: 10.1093/infdis/150.5.728.
In a study of pyelonephritis in children less than two years of age we found a high incidence of acute first-time pyelonephritis among children who had been previously cared for in a particular hospital neonatal ward. In 1981 and 1982 more than 50% of the children with pyelonephritis from the referral area of Danderyd Hospital (Danderyd, Sweden) had previously attended this particular neonatal ward; the expected incidence was 15% (P less than .001). The majority of these cases of pyelonephritis were caused by Escherichia coli that were P fimbriated and of serotype O6:K5. An E. coli strain with the same characteristics was found in the stools of personnel in the neonatal ward and in a high proportion of the stools and cord stumps of neonates in the ward. These findings support the opinion that certain P fimbriated E. coli clones may be nosocomially spread and cause epidemic outbreaks of pyelonephritis and that fecal colonization with such E. coli predisposes to this disease.
在一项针对两岁以下儿童肾盂肾炎的研究中，我们发现，在曾在某一特定医院新生儿病房接受护理的儿童中，首次急性肾盂肾炎的发病率很高。1981年和1982年，来自丹德吕德医院（瑞典丹德吕德）转诊区域的肾盂肾炎患儿中，超过50%曾在该特定新生儿病房就诊；预期发病率为15%（P<0.001）。这些肾盂肾炎病例大多由产P菌毛且血清型为O6:K5的大肠杆菌引起。在新生儿病房工作人员的粪便中，以及病房内高比例的新生儿粪便和脐带残端中，发现了具有相同特征的大肠杆菌菌株。这些发现支持了这样一种观点，即某些产P菌毛的大肠杆菌克隆可能通过医院传播并导致肾盂肾炎的流行暴发，并且这种大肠杆菌的粪便定植易引发该病。
