Wesnes K, Warburton D M
Neuropsychobiology. 1984;11(4):255-9. doi: 10.1159/000118090.
This study compared the effects of single nightly doses of flurazepam 30 mg and temazepam 40 mg upon both the subjective assessment of sleep quality and performance on 3 tests of mental efficiency 10 h following medication. 12 male and 12 female non-smoker subjects took part, none of whom experienced sleep difficulties. In comparison with their respective placebos, both hypnotics produced marked and significant improvements in the quality, depth and duration of sleep, and reduced the difficulty that the female subjects experienced in getting to sleep. Flurazepam also produced a significant increase in satisfaction with sleep together with significant reductions in the number of awakenings during the night and the level of clearheadedness on waking. The major test of performance was a continuous 20-min rapid visual information processing task. It was found that for both sexes during each of the two consecutive 10-min periods of performance flurazepam produced highly significant residual impairments in both the speed of reaction and the accuracy of detection, while temazepam had no effect. Overall the results indicate that flurazepam produces a wider range of improvements in sleep quality than temazepam at the cost of less clearheadedness on waking and residual impairments in sustained rapid information processing.
本研究比较了每晚单次服用30毫克氟西泮和40毫克替马西泮对睡眠质量主观评估以及用药10小时后三项心理效率测试表现的影响。12名男性和12名女性非吸烟受试者参与了研究，他们均无睡眠困难。与各自的安慰剂相比，两种催眠药均使睡眠质量、深度和时长有显著改善，并减轻了女性受试者入睡的困难。氟西泮还显著提高了对睡眠的满意度，同时显著减少了夜间觉醒次数以及醒来时的清醒程度。主要的表现测试是一项持续20分钟的快速视觉信息处理任务。结果发现，在连续两个10分钟的表现期内，无论男女，氟西泮在反应速度和检测准确性方面均产生了高度显著的残留损害，而替马西泮则没有影响。总体而言，结果表明，氟西泮在睡眠质量方面的改善范围比替马西泮更广，代价是醒来时清醒程度较低以及持续快速信息处理存在残留损害。
