Cleophas T J, van Lier H J, Faaber P, Fennis J F, van't Laar A
Angiology. 1984 Nov;35(11):719-23. doi: 10.1177/000331978403501105.
Twenty patients with primary and 11 with secondary Raynaud's syndrome were treated with the alpha-adrenoceptor blocker phenoxybenzamine (10-20 mg daily). In the secondary group mean age and mean duration of symptoms as well as presence of positive ANA and positive Clq binding test were significantly higher than in the primary group. In both groups a beneficial effect of the medication on finger temperature 12 min after finger cooling and on clinical symptoms was established. Secondary Raynaud's syndrome reacted at least as well as primary syndrome.
20例原发性雷诺综合征患者和11例继发性雷诺综合征患者接受了α-肾上腺素能受体阻滞剂酚苄明治疗（每日10 - 20毫克）。继发性组的平均年龄、平均症状持续时间以及抗核抗体阳性和Clq结合试验阳性的比例均显著高于原发性组。两组患者在手指冷却12分钟后用药对手指温度及临床症状均有有益影响。继发性雷诺综合征的反应至少与原发性综合征一样好。
