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不同组胺H2受体拮抗剂对小鼠离体全胃胃酸分泌及豚鼠自主搏动心房心率的影响。

The effect of different histamine H2-receptor antagonists on the gastric acid secretion of the isolated whole stomach of the mouse and on the heart rate of spontaneously beating atrium of the guinea-pig.

作者信息

Szelenyi I, Postius S

出版信息

Arzneimittelforschung. 1984;34(7):787-8.

PMID:6149753
Abstract

The effect of metiamide, cimetidine and 2-[2-[5-(dimethylaminomethyl)furan-2-ylmethylthio]ethylamino]- 5-(6-methylpyrid-3-ylmethyl)-pyrimidin-4-one (SK & F 93 479) was studied on the acid secretion of the isolated stomach of the mouse and on the heart rate of the right atrium of the guinea-pig. The order of potency of histamine H2-antagonists investigated was identical on atrium and stomach, however, the pA2 values obtained on acid secretion were approximately 10 times lower than those found on atrium.

摘要

研究了甲硫米特、西咪替丁和2-[2-[5-(二甲基氨基甲基)呋喃-2-基甲硫基]乙氨基]-5-(6-甲基吡啶-3-基甲基)-嘧啶-4-酮（SK&F 93 479）对小鼠离体胃泌酸及豚鼠右心房心率的影响。所研究的组胺H2拮抗剂在心房和胃上的效价顺序相同，然而，在胃酸分泌上获得的pA2值比在心房上发现的值低约10倍。

相似文献

1
The effect of different histamine H2-receptor antagonists on the gastric acid secretion of the isolated whole stomach of the mouse and on the heart rate of spontaneously beating atrium of the guinea-pig.不同组胺H2受体拮抗剂对小鼠离体全胃胃酸分泌及豚鼠自主搏动心房心率的影响。
Arzneimittelforschung. 1984;34(7):787-8.
2
A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine.新型组胺H2受体拮抗剂乙溴替丁与西咪替丁、雷尼替丁和替奥替丁某些药理特性的比较。
J Pharmacol Exp Ther. 1983 Jan;224(1):171-9.
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Effect of histamine H2-receptor antagonists on blood flow and secretion of the resting and stimulated stomach.组胺H2受体拮抗剂对静息及刺激状态下胃血流量和分泌的影响。
Mater Med Pol. 1981 Jan-Mar;13(1):3-6.
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Histamine H2-receptor antagonistic action of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)acetoxyacetamide hydrochloride (TZU-0460).盐酸N-(3-[3-(1-哌啶基甲基)苯氧基]丙基)乙酰氧基乙酰胺（TZU-0460）的组胺H2受体拮抗作用
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Scand J Gastroenterol Suppl. 1981 Jun;69:1-9.
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[Gastric acid secretion and histamine H2 receptor antagonists].[胃酸分泌与组胺H2受体拮抗剂]
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引用本文的文献

1
Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay.组胺H2受体拮抗剂在小鼠离体胃试验中异常pKB值的进一步分析。
Br J Pharmacol. 1985 Nov;86(3):581-7. doi: 10.1111/j.1476-5381.1985.tb08934.x.