Influence of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413), a new antiallergic, on ciliary movement.

Influence of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazol e difumarate (KB-2413), a new antiallergic agent, on tracheal ciliary movement of pigeons and its local anaesthetic effect were investigated in comparison with reference drugs. KB-2413 (0.3 and 3 mg/kg i.v.) did not affect ciliary movement, but ketotifen, diphenhydramine, chlorpheniramine, lidocaine and tetracaine showed a significantly inhibitory effect on ciliary movement at a dose of 3 mg/kg i.v. KB-2413 (4% solution) did not inhibit corneal reflex in guinea pigs, but ketotifen, diphenhydramine and chlorpheniramine inhibited corneal reflex at 1%, 1% and 4% solution, respectively. KB-2413 (5 X 10(-4) mol/l) did not inhibit action potentials of desheathed frog sciatic nerve fiber, but ketotifen, chlorpheniramine and diphenhydramine inhibited significantly action potentials at 5 X 10(-4) mol/l. These results suggested that KB-2413 did not influence tracheal ciliary movement because of having no local anaesthetic effect.