Onofrio B M
Clin Neurosurg. 1983;31:304-15. doi: 10.1093/neurosurgery/31.cn_suppl_1.304.
The acute administration of intrathecal morphine in man results in analgesia mediated by an opiate receptor. Chronically infused intraspinal opiates have an analgetic action mediated by opiate receptors. Our data appear to indicate that the chronic administration of spinal morphine can provide pain relief for terminal cancer patients for at least 3 months, and that this effect also is mediated by an opiate receptor. There appear to be at least two classes of opiate receptors in the human and animal spinal cords which mediate analgesia. Our preliminary data suggest that, as in the animal model, DADL, a delta-ligand, shows significant activity in a morphine-tolerant spinal cord.
鞘内注射吗啡用于人体时，急性给药会产生由阿片受体介导的镇痛作用。长期注入脊髓的阿片类药物具有由阿片受体介导的镇痛作用。我们的数据似乎表明，长期给予脊髓吗啡可为晚期癌症患者提供至少3个月的疼痛缓解，并且这种作用也是由阿片受体介导的。在人和动物的脊髓中似乎至少有两类介导镇痛作用的阿片受体。我们的初步数据表明，与动物模型一样，δ配体DADL在吗啡耐受的脊髓中显示出显著活性。
