Righi D F, Feldman H A, Smith B T
Comp Biochem Physiol B. 1984;79(1):87-92. doi: 10.1016/0305-0491(84)90082-8.
Dexamethasone induces TAT in the embryonic chick liver, but this effect is not blocked by prior administration of insulin at a dose sufficient to increase the hepatic protein/DNA ratio. Similarly, insulin does not block dexamethasone induction of TAT in chick embryo hepatocytes in vitro. In contrast, insulin reduces TAT induction by dexamethasone in fetal rat hepatocytes by 35-40%. No significant differences in insulin binding were noted between chick and rat hepatocytes.
地塞米松可诱导胚胎鸡肝脏中酪氨酸转氨酶（TAT）的产生，但预先给予足以提高肝脏蛋白质/DNA比率的胰岛素剂量，并不能阻断这种效应。同样，胰岛素也不能在体外阻断地塞米松对鸡胚肝细胞中TAT的诱导作用。相比之下，胰岛素可使地塞米松对胎鼠肝细胞中TAT的诱导作用降低35%-40%。鸡肝细胞和大鼠肝细胞之间在胰岛素结合方面未观察到显著差异。
