阵发性（px）雏鸡脑组织中的γ-氨基丁酸（GABA）

GABA in brain tissue of paroxysmal (px) chick.

作者信息

Firman J D, Beck M M

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;79(1):143-5. doi: 10.1016/0742-8413(84)90176-2.

Abstract

An investigation was made of GABA in whole brain and brain regions of paroxysmal (px) chicks. Whole brain levels of GABA were higher (P less than 0.05) in px chicks than in normal siblings by day 10 post-hatching. GABA in brain areas containing degeneration of auditory and vestibular nuclei and tracts was also found to be higher (P less than 0.05) in px chicks. These data indicate that a dysfunction of the GABA pathway occurs early in the px syndrome, possibly as a causative factor.

摘要

对阵发性（px）雏鸡的全脑和脑区中的γ-氨基丁酸（GABA）进行了一项研究。到孵化后第10天，px雏鸡全脑中GABA的水平高于正常同胞雏鸡（P<0.05）。还发现，在px雏鸡中，含有听觉和前庭核及束退化的脑区中的GABA也更高（P<0.05）。这些数据表明，GABA通路功能障碍在px综合征早期就已出现，可能是一个致病因素。