Yamauchi M, Kimura K, Kawase H, Watanabe Y, Kitahara T, Ogura K, Fujisawa K, Kameda H
Enzyme. 1984;32(2):110-5. doi: 10.1159/000469460.
The activity of gamma-glutamyl transferase (GGT) in the liver of 22 patients with alcoholic liver disease, 24 with nonalcoholic liver disease and 12 normal controls was measured. The enhanced hepatic GGT activity was higher in alcoholic patients and nonalcoholic patients than in the normal controls. No statistical significance of difference could be found in hepatic GGT activity between alcoholic and nonalcoholic patients, while serum GGT activity was markedly elevated in alcoholic patients compared to nonalcoholic patients. There was better correlation between hepatic and serum GGT activity in alcoholic patients. Furthermore the enhanced hepatic GGT activity could contribute to the pathogenesis of liver fibrosis as a result of the investigation for hepatic GGT activity and histological liver fibrosis.
对22例酒精性肝病患者、24例非酒精性肝病患者及12名正常对照者的肝脏中γ-谷氨酰转移酶（GGT）活性进行了测定。酒精性肝病患者和非酒精性肝病患者肝脏中GGT活性增强程度高于正常对照者。酒精性肝病患者和非酒精性肝病患者肝脏GGT活性差异无统计学意义，而酒精性肝病患者血清GGT活性明显高于非酒精性肝病患者。酒精性肝病患者肝脏与血清GGT活性之间存在更好的相关性。此外，通过对肝脏GGT活性与肝脏组织学纤维化的研究发现，肝脏GGT活性增强可能参与肝纤维化的发病机制。
