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[大鼠输精管作为评估化合物作用的测试对象]

[The rat vas deferens as a test object for assessing the action of chemical compounds].

作者信息

Avakian O M

出版信息

Farmakol Toksikol. 1984 Sep-Oct;47(5):104-10.

PMID:6149950
Abstract

The vas deferens is widely used for studies of the action of chemical compounds on adrenergic processes. The recent data indicate that the response of the vas deferens to transmural electric stimulation can be blocked by the substances possessing different properties and that to have a correct assessment of the action of new chemical compounds, of great importance is both the animal species and the characteristics of the strips used (epididymal and prostatic) and electric impulses. The epididymal strip of the rat vas deferens--transmural stimulation by serial electric impulses is a convenient model for screening new chemical compounds.

摘要

输精管被广泛用于研究化合物对肾上腺素能过程的作用。最近的数据表明,输精管对跨壁电刺激的反应可被具有不同特性的物质阻断,并且要正确评估新化合物的作用,动物种类以及所用条带(附睾和前列腺的)特性和电脉冲都非常重要。大鼠输精管的附睾条带——通过连续电脉冲进行跨壁刺激是筛选新化合物的便捷模型。

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