Effects of somatostatin, glucagon and insulin on glycogen synthesis in isolated rat hepatocytes.

The effects of somatostatin on basal and hormone-mediated rates of glycogenesis were studied in isolated rat hepatocytes. Somatostatin (1.5 X 10(-11) - 1.5 X 10(-8) M) had no effect on glycogen synthesis in the presence of 30 mM glucose and did not overcome a glucagon (1.5 X 10(-10) M)-induced inhibition of glycogenesis.