Tollefson G, Lesar T, Grothe D, Garvey M
Am J Psychiatry. 1984 Dec;141(12):1612-3. doi: 10.1176/ajp.141.12.1612.
An elderly woman developed a high serum digoxin concentration resulting in toxicity when alprazolam was added to her digoxin therapy. The reduced renal clearance of digoxin is postulated as the mechanism for this interaction.
一名老年女性在接受地高辛治疗时加用了阿普唑仑,导致血清地高辛浓度升高并产生毒性。地高辛肾清除率降低被认为是这种相互作用的机制。