Jeffries J, Remington G, Wilkins J
Can J Psychiatry. 1984 Nov;29(7):601-4. doi: 10.1177/070674378402900711.
The question of lithium-haloperidol incompatibility has been debated for a number of years now. The difficulty remains in distinguishing a combined toxicity syndrome, rather than toxicity to either agent alone. The authors reviewed a further case of adverse drug response following the concomitant use of lithium and haloperidol. It is their conclusion that a combined toxicity syndrome does exist, although it remains for future investigations to determine whether this effect is additive or synergistic. Finally, the possibility of underlying organic susceptibility is raised with reference to the case presented here.
锂与氟哌啶醇不相容性的问题已经争论多年了。困难在于区分合并毒性综合征，而不是单独对任何一种药物的毒性。作者回顾了另一例锂和氟哌啶醇联合使用后出现药物不良反应的病例。他们的结论是确实存在合并毒性综合征，尽管这种效应是相加的还是协同的仍有待未来研究确定。最后，参照此处呈现的病例，提出了潜在机体易感性的可能性。
