Krizsa F, Cserháti I
Haematologia (Budap). 1977;11(1-2):149-54.
F-leurosine (formyl-leurosine) was found to exert a thrombocytopoietic effect in CFLP mice. The effect was most pronounced in a dose of 1.0 mg/kg. The increased activity of the megakaryocyte system was not due to thrombocytopenia. The preparation induced in the bone marrow an increasing megakaryocyte formation (increase of the megakaryocyte index, a shift to the left in the qualitative composition of the giant cells, increase of the 75Se-methionine incorporation). F-leurosine seems to exert its effect through a direct stimulation of the megakaryocyte system, which might be utilized in therapy.
F-长春花碱（甲酰长春花碱）被发现对CFLP小鼠有促进血小板生成的作用。该作用在剂量为1.0mg/kg时最为明显。巨核细胞系统活性的增加并非由于血小板减少。该制剂在骨髓中诱导巨核细胞生成增加（巨核细胞指数增加、巨细胞定性组成向左移、75Se-蛋氨酸掺入增加）。F-长春花碱似乎通过直接刺激巨核细胞系统发挥作用，这可能在治疗中得到应用。
