Pruneau D, Mainguy Y, Roy F
Eur J Pharmacol. 1984 Oct 15;105(3-4):343-6. doi: 10.1016/0014-2999(84)90629-0.
The specificity of the alpha-adrenergic blockade by trifluoperazine was tested in pithed rats. Trifluoperazine reduced the pressor effects of (-)-noradrenaline. The log dose-response curve to methoxamine, an alpha 1-agonist, was shifted to the right whereas the vasopressor responses to BHT-920, an alpha 2-agonist, were unaffected by trifluoperazine. It was concluded that trifluoperazine acts as a peripheral vascular alpha 1-antagonist in the rat.
在脊髓麻醉大鼠中测试了三氟拉嗪对α-肾上腺素能的阻断特异性。三氟拉嗪降低了（-）-去甲肾上腺素的升压作用。α1-激动剂甲氧明的对数剂量-反应曲线右移，而α2-激动剂BHT-920的血管升压反应不受三氟拉嗪影响。得出的结论是，三氟拉嗪在大鼠中作为外周血管α1-拮抗剂起作用。
