温度对皮肤静脉对刺叶番荔枝提取物反应性的影响。

Effect of temperature on the responsiveness of cutaneous veins to the extract of Ruscus aculeatus.

作者信息

Rubanyi G, Marcelon G, Vanhoutte P M

出版信息

Gen Pharmacol. 1984;15(5):431-4. doi: 10.1016/0306-3623(84)90045-4.

Abstract

In canine cutaneous veins cooling augments and warming depresses the responses to sympathetic nerve stimulation. In these veins the extract of Ruscus aculeatus (Ruscus) causes contractions due to alpha-adrenergic activation. To determine the effects of temperature on the response to Ruscus, rings of canine saphenous veins were studied at 24 degrees, 37 degrees and 41 degrees C. At 37 degrees C, Ruscus caused an increase in isometric tension which was depressed by prazosin and rauwolscine. Cooling inhibited the response to Ruscus, while warming augmented it. Rauwolscine potentiated, and prazosin reversed the effect of cooling on contractions evoked by Ruscus. Prazosin reduced, and rauwolscine augmented the effect of warming. These experiments demonstrate that temperature affects the venoconstriction induced by Ruscus in an opposite fashion as that to sympathetic nerve activation, presumably because the alpha 1-adrenergic component of the response to Ruscus predominates.

摘要

在犬类皮肤静脉中，降温会增强、升温会抑制对交感神经刺激的反应。在这些静脉中，刺路蓟提取物（刺路蓟）由于α-肾上腺素能激活而引起收缩。为了确定温度对刺路蓟反应的影响，在24℃、37℃和41℃下研究了犬隐静脉环。在37℃时，刺路蓟引起等长张力增加，哌唑嗪和萝芙木碱可抑制这种增加。降温抑制了对刺路蓟的反应，而升温则增强了反应。萝芙木碱增强了反应，哌唑嗪则逆转了降温对刺路蓟诱发收缩的影响。哌唑嗪降低了升温的影响，而萝芙木碱增强了升温的影响。这些实验表明，温度以与交感神经激活相反的方式影响刺路蓟诱导的静脉收缩，推测是因为对刺路蓟反应中的α1-肾上腺素能成分占主导。