Serby M, Richardson S B, Twente S, Siekierski J, Corwin J, Rotrosen J
Neurobiol Aging. 1984 Fall;5(3):187-9. doi: 10.1016/0197-4580(84)90061-7.
Studies have previously demonstrated low somatostatin levels in autopsy cortical tissue from Alzheimer's disease (AD) patients and low somatostatin levels in CSF obtained from subjects with dementia. We evaluated levels of this peptide in 21 non-depressed subjects, 10 with AD, 2 with Parkinson's disease (PD), and 9 with other neurological conditions. The AD patients had significantly lower mean CSF somatostatin than the "other" neurological patients (14.6 +/- 1.5 S.E.M. versus 26.7 +/- 3.2 pg/ml, p less than 0.005). A demented PD subject had a level in the range of the AD group, while the non-demented PD patient had a value above this range. Thus, all 11 patients with AD or PD dementia, analogous disorders, had levels below 21.8 mg/ml, while 7 of the 10 remaining patients had values above 21.8 pg/ml. Age did not explain this finding.
此前的研究已证明，阿尔茨海默病（AD）患者尸检的皮质组织中生长抑素水平较低，且从患有痴呆症的受试者获取的脑脊液中生长抑素水平也较低。我们评估了21名非抑郁症受试者、10名AD患者、2名帕金森病（PD）患者以及9名患有其他神经系统疾病的受试者体内这种肽的水平。AD患者脑脊液中生长抑素的平均水平显著低于“其他”神经系统疾病患者（分别为14.6±1.5标准误与26.7±3.2 pg/ml，p<0.005）。一名患有痴呆症的PD受试者的水平处于AD组范围内，而未患痴呆症的PD患者的值高于此范围。因此，所有11名患有AD或PD痴呆症（类似病症）的患者，其水平均低于21.8 mg/ml，而其余10名患者中有7名的值高于21.8 pg/ml。年龄并不能解释这一发现。
