β-肾上腺素能受体阻滞剂对健康、未受过体育训练的人的运动表现和呼吸反应的影响。
Effects of beta-adrenoceptor blockade on exercise performance and respiratory response in healthy, physically untrained humans.
作者信息
Violante B, Buccheri G, Brusasco V
出版信息
Br J Clin Pharmacol. 1984 Dec;18(6):811-5. doi: 10.1111/j.1365-2125.1984.tb02549.x.
Abstract
The effects of propranolol 80 mg orally were compared with those of placebo on the response to a stepwise increasing exercise test in 17 healthy and physically untrained volunteers, of whom eight were female. Propranolol showed no significant effects on maximum work rate or perceived exertion rate. However, submaximal O2 uptake, CO2 output and minute ventilation tended to be lower after propranolol than after placebo. It is concluded that in subjects with a low work capacity, beta-adrenoceptor blockade does not impair maximal exercise capacity. The mechanisms underlying changes in respiratory response to exercise after propranolol are not fully explained. However, changes in substrate utilisation, the reduction in cardiac output and an alteration in respiratory drive may all be involved.
摘要
在17名健康且未经体育训练的志愿者（其中8名女性）中，比较了口服80毫克普萘洛尔与安慰剂对逐步递增运动试验反应的影响。普萘洛尔对最大工作率或主观用力率无显著影响。然而，普萘洛尔给药后，次最大摄氧量、二氧化碳排出量和分钟通气量往往低于安慰剂给药后。得出的结论是，在工作能力较低的受试者中，β-肾上腺素能受体阻滞不会损害最大运动能力。普萘洛尔给药后运动时呼吸反应变化的潜在机制尚未完全阐明。然而，底物利用的变化、心输出量的降低和呼吸驱动的改变可能都与之有关。
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