Han Z Y, Xiao R Q
Int J Gynaecol Obstet. 1984 Aug;22(4):319-24. doi: 10.1016/0020-7292(84)90091-2.
A comparative clinical study was undertaken by the Sichuan Cooperative Research Group for Microencapsulated Contraceptives to assess the efficacy of intramuscular microencapsulated megestrol compound as a long-acting contraceptive and to find the optimal dosage as regards efficacy, side effects and menstrual irregularities. Eight hundred twenty eight women were divided into four groups and injected monthly with four different dosage combinations that consisted of megestrol acetate and estradiol valerate. In all, 5298 dosage cycles were observed. The investigation indicated that microencapsulation effectively prolonged contraceptive effect of the short-acting agents, reduced the required dosage and lowered the incidence of side effects. A combination of 15 mg megestrol acetate and 5 mg estradiol valerate, as compared to the other three regimens, was found to be clinically most acceptable because of the lower incidence of menstrual irregularities.
四川微囊避孕药合作研究组开展了一项对比临床研究，以评估复方甲地孕酮微囊注射液作为长效避孕药的效果，并找出在疗效、副作用和月经不调方面的最佳剂量。828名女性被分为四组，每月注射四种由醋酸甲地孕酮和戊酸雌二醇组成的不同剂量组合。总共观察了5298个剂量周期。调查表明，微囊化有效地延长了短效药物的避孕效果，减少了所需剂量，并降低了副作用的发生率。与其他三种方案相比，发现15毫克醋酸甲地孕酮和5毫克戊酸雌二醇的组合在临床上最可接受，因为月经不调的发生率较低。
