Sutherland D E, Goetz F C, Najarian J S
Diabetes. 1980;29 Suppl 1:10-8. doi: 10.2337/diab.29.1.s10.
Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo later after resumption of exogenous insulin therapy. In both patients, carbohydrate metabolism was nearly normal during the period of graft function. Two patients died of infectious complications between 1 and 2 mo after transplantation. The main hazard of pancreas transplantation relates to the immunosuppression necessary to prevent rejection, setting the stage for infectious complications. Technically, pancreas transplantation is a feasible and efficient procedure, and, if better methods are developed for preventing rejection, it should be applicable to patients prone to develop secondary complications of diabetes.
将未结扎导管的节段性胰腺同种异体移植经腹腔移植到5例2年多前已接受肾移植的糖尿病患者体内。1例患者在10.5个月后移植肾仍存活且功能良好。2例患者分别在大约2个月和3个月时移植肾发生排斥反应，但在重新开始外源性胰岛素治疗后8 - 9个月仍存活。在这2例患者中，移植肾功能期碳水化合物代谢几乎正常。2例患者在移植后1至2个月之间死于感染性并发症。胰腺移植的主要风险与预防排斥反应所需的免疫抑制有关，这为感染性并发症埋下了隐患。从技术上讲，胰腺移植是一种可行且有效的手术方法，如果能开发出更好的预防排斥反应的方法，它应该适用于易发生糖尿病继发并发症的患者。
