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转录调控和酶失活在大肠杆菌氨甲酰磷酸合成酶合成中的作用。

Role of transcriptional regulation and enzyme inactivation in the synthesis of Escherichia coli carbamoylphosphate synthase.

作者信息

Piérard A, Lissens W, Halleux P, Cunin R, Glansdorff N

出版信息

J Bacteriol. 1980 Jan;141(1):382-5. doi: 10.1128/jb.141.1.382-385.1980.

DOI:10.1128/jb.141.1.382-385.1980
PMID:6153385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293605/
Abstract

The question of posttranscriptional control during cumulative repression of Escherichia coli carbamoylphosphate synthase has been examined by following the kinetics of repression and by comparing messenger ribonucleic acid and enzyme levels after growth under various conditions. The data provide no evidence for control of synthesis at a level other than transcription. They suggest, however, that enzyme inactivation (or turnover) plays a significant role in the establishment of repressive conditions.

摘要

通过追踪阻遏动力学以及比较在各种条件下生长后信使核糖核酸和酶的水平，对大肠杆菌氨甲酰磷酸合酶累积阻遏过程中的转录后调控问题进行了研究。数据没有提供除转录水平之外其他合成调控的证据。然而，它们表明酶的失活（或周转）在建立阻遏条件中起重要作用。

相似文献

1
Role of transcriptional regulation and enzyme inactivation in the synthesis of Escherichia coli carbamoylphosphate synthase.转录调控和酶失活在大肠杆菌氨甲酰磷酸合成酶合成中的作用。
J Bacteriol. 1980 Jan;141(1):382-5. doi: 10.1128/jb.141.1.382-385.1980.
2
In vitro synthesis of Escherichia coli carbamoylphosphate synthase: evidence for participation of the arginine repressor in cumulative repression.大肠杆菌氨甲酰磷酸合成酶的体外合成：精氨酸阻遏物参与累积阻遏的证据。
J Bacteriol. 1980 Jan;141(1):58-66. doi: 10.1128/jb.141.1.58-66.1980.
3
Repression of Escherichia coli carbamoylphosphate synthase: relationships with enzyme synthesis in the arginine and pyrimidine pathways.大肠杆菌氨甲酰磷酸合成酶的抑制作用：与精氨酸和嘧啶途径中酶合成的关系
J Bacteriol. 1976 Jul;127(1):291-301. doi: 10.1128/jb.127.1.291-301.1976.
4
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DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12.carA基因的DNA序列以及carAB的控制区域：串联启动子分别受精氨酸和嘧啶调控，调节大肠杆菌K-12中氨甲酰磷酸合成酶的合成。
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Gamma-irradiation resistant mutants of Escherichia coli: modified enzyme synthesis repressible by arginine and uracil.大肠杆菌的γ射线抗性突变体：经精氨酸和尿嘧啶抑制的修饰酶合成
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引用本文的文献

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Regulation of carbamoylphosphate synthesis in Escherichia coli: an amazing metabolite at the crossroad of arginine and pyrimidine biosynthesis.大肠杆菌中氨甲酰磷酸合成的调控：精氨酸和嘧啶生物合成交汇点处的神奇代谢物。
Amino Acids. 2018 Dec;50(12):1647-1661. doi: 10.1007/s00726-018-2654-z. Epub 2018 Sep 20.
2
Multiple regulatory signals in the control region of the Escherichia coli carAB operon.大肠杆菌carAB操纵子调控区域中的多种调控信号。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4139-43. doi: 10.1073/pnas.81.13.4139.
3
Molecular basis for modulated regulation of gene expression in the arginine regulon of Escherichia coli K-12.大肠杆菌K-12精氨酸调节子中基因表达调控的分子基础。
Nucleic Acids Res. 1983 Aug 11;11(15):5007-19. doi: 10.1093/nar/11.15.5007.
4
DNA sequence of the carA gene and the control region of carAB: tandem promoters, respectively controlled by arginine and the pyrimidines, regulate the synthesis of carbamoyl-phosphate synthetase in Escherichia coli K-12.carA基因的DNA序列以及carAB的控制区域：串联启动子分别受精氨酸和嘧啶调控，调节大肠杆菌K-12中氨甲酰磷酸合成酶的合成。
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In vitro synthesis of Escherichia coli carbamoylphosphate synthase: evidence for participation of the arginine repressor in cumulative repression.大肠杆菌氨甲酰磷酸合成酶的体外合成：精氨酸阻遏物参与累积阻遏的证据。
J Bacteriol. 1980 Jan;141(1):58-66. doi: 10.1128/jb.141.1.58-66.1980.
6
Biosynthesis and metabolism of arginine in bacteria.细菌中精氨酸的生物合成与代谢
Microbiol Rev. 1986 Sep;50(3):314-52. doi: 10.1128/mr.50.3.314-352.1986.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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TOPOGRAPHY OF COTRANSDUCIBLE ARGININE MUTATIONS IN ESCHERICHIA COLI K-12.大肠杆菌K-12中可共转导精氨酸突变的拓扑学
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In vitro synthesis of Escherichia coli carbamoylphosphate synthase: evidence for participation of the arginine repressor in cumulative repression.大肠杆菌氨甲酰磷酸合成酶的体外合成：精氨酸阻遏物参与累积阻遏的证据。
J Bacteriol. 1980 Jan;141(1):58-66. doi: 10.1128/jb.141.1.58-66.1980.
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Regulation and mutation affecting a glutamine dependent formation of carbamyl phosphate in Escherichia coli.影响大肠杆菌中谷氨酰胺依赖性氨甲酰磷酸形成的调控与突变
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Regulation at the level of translation in the arginine pathway of Escherichia coli K12.大肠杆菌K12精氨酸途径中翻译水平的调控。
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7
Tryptophan messenger translation in Escherichia coli.色氨酸信使在大肠杆菌中的翻译
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8
Letter: Divergent transcription in the argECBH cluster of genes in Escherichia coli K12.信函：大肠杆菌K12中argECBH基因簇的分歧转录
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Transient regulation of enzyme synthesis in Escherichia coli.大肠杆菌中酶合成的瞬时调控
Mol Gen Genet. 1973;121(1):77-81. doi: 10.1007/BF00353695.
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Physiology and genetics of carbamoylphosphate synthesis in Escherichia coli K12.大肠杆菌K12中氨甲酰磷酸合成的生理学与遗传学
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