Shabbo F P, Wain W H, Ross D N
Thorac Cardiovasc Surg. 1980 Feb;28(1):21-5. doi: 10.1055/s-2007-1022045.
One hundred and four patients with complex congenital heart disease were operated between 1966 and 1978 for reconstruction of the right ventricular outflow using an aortic homograft conduit. The average age was 14 years, ranging between 3 years and 28 years of age with an equal male/female ratio. Hospital mortality was 50% and there were 3 late deaths (6%) amongst the surviving 52 patients. Seventy-nine percent of the survivors are well and asymptomatic between 1 year and 12 years follow-up. Only 2 patients (4%) developed homograft conduit obstruction with a peak systolic gradient over 40 mmHg and 1 patient needed reoperation 9 years after the original primary reconstruction. Thirty-one patients underwent cardiac catheterization between 1 year and 9 years following the original operation, and a further 9 patients underwent a second cardiac catheterization at a mean of 36 months after their first cardiac catheterization. Ninety-three percent of these 31 patients had a resting peak systolic gradient across the homograft conduit of between 0 and 55 mmHg (mean 14.16 +/- 14.03). Calcification in the wall of the aortic homograft appeared within the first 2 years in about 80% of the patients but this had no correlation to the gradient across the homograft, nor did it interfere with the valve performance.
1966年至1978年间，104例复杂先天性心脏病患者接受了手术，使用主动脉同种异体移植管道重建右心室流出道。平均年龄为14岁，年龄范围在3岁至28岁之间，男女比例相等。医院死亡率为50%，在存活的52例患者中有3例晚期死亡（6%）。79%的幸存者在1年至12年的随访期间情况良好且无症状。只有2例患者（4%）出现同种异体移植管道梗阻，收缩期峰值梯度超过40 mmHg，1例患者在初次重建9年后需要再次手术。31例患者在初次手术后1年至9年接受了心导管检查，另有9例患者在首次心导管检查后平均36个月接受了第二次心导管检查。这31例患者中有93%的患者经同种异体移植管道的静息收缩期峰值梯度在0至55 mmHg之间（平均14.16±14.03）。约80%的患者在最初2年内主动脉同种异体移植管壁出现钙化，但这与同种异体移植管道两端的压力梯度无关，也不影响瓣膜功能。
