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[人肾肿瘤中两种α2-糖蛋白的免疫化学和物理化学比较研究]

[Comparative immunochemical and physicochemical study of 2 alpha-glycoproteins from human kidney tumors].

作者信息

Pchelkina Z M, Matveev B P, Rykunov E I, Terent'ev A A

出版信息

Vopr Med Khim. 1980 Jan-Feb;26(1):78-81.

PMID:6154384
Abstract

Using immunochemical methods two "divergent" antigens were identified in tumors of kidney; these antigens were not found in normal kidney, but were observed in several other normal tissues. Both antigens were alpha-glycoproteins. Immunochemical analysis was carried out to find these proteins in extracts of normal tissues, in malignant tumors of kidney as well as in blood serum of patients with the kidney tumors. These proteins were-dissimilar in immunochemical properties and also in some physico-chemical characteristics; one of them was a thermostable protein and the other one was able to bind estrogens.

摘要

运用免疫化学方法,在肾肿瘤中鉴定出两种“不同的”抗原;这些抗原在正常肾脏中未被发现,但在其他几种正常组织中被观察到。两种抗原均为α - 糖蛋白。进行免疫化学分析以在正常组织提取物、肾恶性肿瘤以及肾肿瘤患者的血清中寻找这些蛋白质。这些蛋白质在免疫化学性质以及一些物理化学特性方面存在差异;其中一种是热稳定蛋白,另一种能够结合雌激素。

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