乙硫氨酸处理大鼠肝脏中含聚腺苷酸的RNA
Poly(A)-containing RNA in the livers of ethionine-treated rats.
作者信息
Dennis J, Kisilevsky R
出版信息
Can J Biochem. 1980 Mar;58(3):230-5. doi: 10.1139/o80-032.
DOI:10.1139/o80-032
PMID:6154513
Abstract
Ethionine intoxication in nonfasted rats leads to a rapid change in the levels of poly(A)+ RNA. Prolonged fasting causes a decrease in poly(A)+ RNA which is not aggravated further by ethionine. The size distribution of poly(A) tracts at the 3' end of mRNA is not affected by ethionine. However, ethionine induces a change in the metabolism of the poly(A) sequence relative to the remainder of the mRNA.
摘要
未禁食大鼠的乙硫氨酸中毒会导致多聚腺苷酸（poly(A)）+ RNA水平迅速变化。长期禁食会导致多聚腺苷酸（poly(A)）+ RNA减少，而乙硫氨酸不会使其进一步加重。信使核糖核酸（mRNA）3'端多聚腺苷酸（poly(A)）序列的大小分布不受乙硫氨酸影响。然而，相对于mRNA的其余部分，乙硫氨酸会诱导多聚腺苷酸（poly(A)）序列代谢发生变化。
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