肝脏疾病中碱性磷酸酶的来源及临床意义。
The source and clinical significance of alkaline phosphatases in liver diseases.
作者信息
Volek V, Stĕpán J
出版信息
Acta Univ Carol Med Monogr. 1977(78 Pt 2):55-8.
The authors studied total serum alkaline phosphatase (E.C. 3.1.3.1) activity and its isoenzyme spectrum 1) in relation to the activity of liver diseases, 2) in relation to cholestatic and non-cholestatic liver diseases. The isodistribution of the alkaline phosphatase isoenzymes (the bone, liver and intestinal fraction) in the serum was studied by the heat inactivation and inhibition method and by electrophoretic separation on agar gel. The results showed that alkaline phosphatase had a close diagnostic bearing not only on cholestatic forms of hepatobiliary diseases, but also on the activity of liver disease. The main source of elevated serum alkaline phosphatase activity in the serum of patients with hepatobiliary diseases is the liver isoenzyme. In the serum alkaline phosphatase isoenzymogram, an abnormally large proportion of this isoenzyme is found more frequently than elevation of total alkaline phosphatase activity.
作者研究了血清总碱性磷酸酶（E.C. 3.1.3.1）活性及其同工酶谱：1）与肝脏疾病活性的关系；2）与胆汁淤积性和非胆汁淤积性肝脏疾病的关系。采用热灭活和抑制法以及琼脂凝胶电泳分离法研究了血清中碱性磷酸酶同工酶（骨、肝和肠部分）的等分布情况。结果表明，碱性磷酸酶不仅对肝胆疾病的胆汁淤积形式具有密切的诊断意义，而且对肝脏疾病的活性也有密切诊断意义。肝胆疾病患者血清中碱性磷酸酶活性升高的主要来源是肝脏同工酶。在血清碱性磷酸酶同工酶图谱中，该同工酶比例异常增大的情况比总碱性磷酸酶活性升高更为常见。
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