多发性硬化症中自然杀伤细胞功能障碍：一种可能的致病因素。
Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor.
作者信息
Benczur M, Petrányl G G, Pálffy G, Varga M, Tálas M, Kotsy B, Földes I, Hollán S R
出版信息
Clin Exp Immunol. 1980 Mar;39(3):657-62.
Abstract
Natural killer (NK) cell activity, antibody-dependent cytotoxicity (ADCC) and the effect of interferon on NK activity was investigated in multiple sclerosis (MS) patients. NK activity measured against K-562 tumour cell line was found to be significantly low in MS patients, and this was most pronounced in the group of male patients with definitive disease. The response of NK cells to interferon proved to be impaired and almost no activation could be demonstrated in response to polyinosinic-polycytidylic acid (poly I:C). Preliminary data obtained by the determination of interferon production in several definitive MS cases reflect a defect in the interferon producing capacity of lymphocytes. The possible involvement of impaired NK cell function in the aetiopathogenesis of MS is discussed.
摘要
对多发性硬化症（MS）患者的自然杀伤（NK）细胞活性、抗体依赖性细胞毒性（ADCC）以及干扰素对NK活性的影响进行了研究。发现MS患者针对K-562肿瘤细胞系测得的NK活性显著降低，在明确诊断为该病的男性患者组中最为明显。事实证明，NK细胞对干扰素的反应受损，对聚肌苷酸-聚胞苷酸（poly I:C）几乎没有激活反应。通过测定几例明确诊断为MS的病例中的干扰素产生情况获得的初步数据反映出淋巴细胞产生干扰素的能力存在缺陷。文中讨论了NK细胞功能受损在MS病因发病机制中可能的作用。
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